Recent Research on GliSODin

 GliSODin is the first orally-effective delivery of SOD, and it has been extensively studied in laboratory models and human clinical research, demonstrating its ability  to promote the body's natural antioxidant defense system.

Numerous clinical studies have shown this action to help protect mitochondrial DNA from oxidative stress, inhibit photo-oxidative stress in the sun-sensitive, inhibit lactic acid accumulation under exercise, restore normal levels of SOD, and positively affect other significant markers of oxidative stress.

Please find following links to the research supporting GliSODin's benefits.

  • - this research site is hosted by, a research community dedicated to the understanding and advancement of GliSODin.  This is a non-commercial site providing links to published studies and copies of many studies pending publication.
  • GliSODin Research Development Timeline  - A graphical representation of the key milestones in the research and development of GliSODin.  (posted with permission)
  • GliSODin Monograph 2012 - A review of the discovery, mechanism of action and human research supporting GliSODin.
  • Contact - For more information on any of the studies, please contact Scott Rosenbush at PLT Health Solutions.
GliSODin Bibliography - A list of germane research

Human Studies

P Humbert, "Could a photobiological test be a suitable method to assess the antioxidant effect of a nutritional supplement (GliSODin)?" The European Journal of Dermatology, vol 17 no 3 May/June 2007

M. Cloarec, et. al. "GliSODin, a Vegetal SOD with Gliadin, as Preventative Agent VS. Atherosclerosis, as Confirmed with Carotid Ultrasound-B Imaging," European Annuals of Allergy & Clinical Immunology vol 39 no 2 2007

Kick, et. al., "Effects of a cantaloupe melon extract/wheat gliadin (GliSODin®) biopolymer during aortic cross-clamping," Journal Intensive Care Medicine 10.1007/s00134-006-0518-6

A Calenda, "Relationship between Relationship between Metabolic Syndrome and GliSODin" Pharmaceutical Sciences, Angers, France, 2006

Muth, Y. Glenz, M. Klaus, P. Radermacher, Guenter Speit, X. Leverve. "Influence of an orally effective SOD on hyperbaric, oxygen related cell damage," Free Radical Research 38:9 (2004) pp. 927-932

F J Menvielle-Bourg, "Superoxide Dismutase (SOD), a Powerful Antioxidant, is now Available Orally" Phytotherapie (2005) Numero 3: 118-121

M. Mac-Mary, J. Sainthillier, P. Creidi, J.P. Series, F. Vix, Ph. Humbert, "Evaluation of the Effect of GliSODin on the Intensity of Actinic Erythema," presented at the CARD (Annual Congress of Dermatological Research) meeting in Brest, France, May 28th 2005

"GliSODin TRIAL," an open study conducted in France on 15 patients presenting fragile skin, hypersensitivity to the sun or even problems of sun disease, conducted by Catherine LAVERDET, MD, Dermatologist, Attache de Consultation des Hepitaux de, Paris. July-September 2003

"GliSODin and Exposure to the Sun," an open study conducted in France on 150 patients by 40 dermatologists following a protocol compiled by Catherine Laverdet, M.D., Nadine Pomarede, M.D. and Catherine Oliveres-Ghouti, M.D. Sponsored by ISOCELL Nutra, France. March 2005

Tkachenko E., Uspensky U., Avaluev E., Oreshko L., "Research of in-patient efficaciousness of the biologically active addition to food GliSODin in therapeutic practice," St. Petersburg State Medical Academy, St. Petersburg, Russia. 2005

S. Arent, D. DiFabio, J. Greenwood, J. Pellegrino, C. Williams, "Nutritional Supplementation In Male College Soccer Players: Effects On Performance And Oxidative Stress," Human Performance Lab, Rutgers University, New Brunswick, NJ. 2005

Rahman H., Rocco R., Tabassum V. "The effects of a specialized superoxide dismutase nutritional supplement for HIV patients on HAART" Center for Family of Health of St. Mary's, Hoboken NJ. 2004 Contributed by Millennium Biotechnologies, Inc.

1Y. Hong, S. Hong, Y.H. Chang. S.H. Cho. "Influence of an orally effective superoxie dismutase (glisodin) on strenuous exercise induced changes of blood antioxidant enzymes and plasma lactate," presented at the American Association for Clinical Chemistry (AACC),National Meeting, July 2004

H. Chenal, A. Davit-Spraul, J. Brevet, A. Legrand, J. Demouzon, C. Cosson. B. Dugas, L. Montagnier, M. Conti. "Restored antioxidant circulating capacities in AIDS west african patients receiving an antioxidant nutraceutical Cucumis melo extract rich in superoxide dismutase activity," 2004 (Abstract to be presented at XVI International AIDS Conference 8/06)

In vitro & In vivo studies

P. Sicard, et. al., "Dietary Superoxide Dismutase Protects Against Light-Induced Retinal Oxidative Stress in Young Senescence Accelerated Mice (SAM)," Invest Ophthalmol Vis Sci 2006;47: E-Abstract 2089

F Okada, et. al., "Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase." British Journal of Cancer (2006) 94, 854-862C.

Naito, Y., et al. "Reduction of diabetes-induced renal oxidative stress by a cantaloupe melon extract/gliadin biopolymers, oxykine, in mice" Biofactors. 2005; 23:85-95.

Jiang Yan Zhou, Patrice Prognon, "Raw material enzymatic activity determination: A specific case for validation and comparison of analytical methods: The example of superoxide dismutase (SOD)" Journal of Pharmaceutical and Biomedical Analysis 18 March 2006; 1143-1148

I, Vouldoukis, M. Conti, P. Krauss, C. Kamate, S. Blazquez, M. Tefit, D. Mazier, A. Calenda, B. Dugas. "Supplementation with gliadin-combined plant superoxide dismutase extracts promotes antioxidant defenses and protects against oxidative stress," Phytotherapy Res Mar 1;18(12) (2004) 957-962

M. Albicini, J. Kick, B. Hauser, U. Ehrmann, X. Leverve, P. Radermacher, G. Speit, C.M. Muth "The Orally Effective Mixture of Sod and Gliadin (GliSODin®) Pr otects Against Oxidative DNA Damage," presented at the 11th Congress of the European Shock Society, January 27-30, 2005

K. Kramer, H. Dijkstra, A. Bast. "Control of physical exercise of rats in a swimming basin," Physiol Behavior. (1993) Feb;53(2):271-6

A. Wozniak, G. Drewa, G.Chesy, A. Rakowski, M. Rozwodowka, D. Olszewska. "Effect of altitude training on the peroxidation and antioxidant enzymes in sportsmen," Medical Science Sports Exercise (2001) Jul;33(7) 1109-13

 F. Marzatico, O. Pansarasa, L. Bertorelli, L. Somenzini, G. Della Valle. "Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidemic performances in highly-trained aerobic and sprint athletes," Journal of Sports Medicine andPhysical Fitness.(1997) Dec. 37(4) 235-9

Marikovsky, V. Ziv , N. Nevo. C. Harris-Cerruti, O. Mahler. "Cu/Zn superoxide dismutase plays important role in immune response," J. Immunology.(2003) Mar 15;170(6):2993-3001

A. Gow, H. Ischiropoulos. "Super-SOD: superoxide dismutase chimera fights off inflammation," American Journal Physiol Lung Cell Mol Physiol. (2003) June; 284(6):L915-6

VL. Kinnula, JD. Crapo. "Superoxide dismutases in the lung and human lung diseases," American Journal Respiratory Critical Care Medicine.(2003) Jun 15;167(12):1600-19

I. Vouldoukis, V. Sivan, M.C. Vozenin, C. Kamate, A. Calenda, D. Mazier, B. Dugas. "Fc-receptor-mediated intracellular delivery of Cu/Zn-superoxide dismutase (SOD1) protects against redox-induced apoptosis through a nitric oxide dependent mechanism," Molecular Medicine. (2000) 6 (12) 1042

I. Vouldoukis, D. Lacan, C. Kamate, P. Coste, A. Caldnda, D. Mazier, M. Conti, B. Dugas. "Antioxidant and anti-inflammatory properties of a Cucumis melo extract rich in superoxide dismutase activity," J.Ethnopharmacology. 94 (2004) 67-75

B. Dugas, N. Dugas, M. Conti, A. Calenda, P. Pino, Y. Thomas, D. Mazier, I. Vouldoukis. "Wheat gliadine promotes the Interleukin-4 induced IgEproduction by normal human peripheral mononuclear cells through a redox dependent mechanism," Cytokine 21, (2003) 1-11

Vouldoukis, M. Conti, JP. Kolb, A.Calenda, D. Mazier, B. Dugas. "Induction of Th1- dependant immunity by an orally effective melon SOD extract," Research Trends, in Current Trends in Immunology," 5, (2003) 141-145

SOD/Gliadin - The Ultimate Defense Against Disease and Aging by Carl Germano, R.D., C.N.S., L..D.N. Published by Twin Streams Kensington 2001

GliSODin -
The Anti-Aging and Antioxidant Catalyst published by Live Well Publishing 2005 (forward by Carl Germano, R.D., C.N.S., L..D.N)



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